A CHEMICAL-GENETIC STRATEGY REVEALS DISTINCT TEMPORAL REQUIREMENTS FOR SAD-1 KINASE IN NEURONAL POLARIZATION AND SYNAPSE FORMATION

A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation

Abstract Background Neurons assemble into a functional network through a sequence of developmental processes including neuronal polarization and synapse formation.In Caenorhabditis elegans, the serine/threonine SAD-1 kinase is essential for proper neuronal polarity and synaptic organization.To determine if SAD-1 activity regulates the establishment

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Multi-Layer, Multi-Segment Iterative Optimization for Maritime Supply Chain Operations in a Dynamic Fuzzy Environment

This study aims to develop a multi-layer, multi-segment iterative optimization algorithm for the operations of a single agent, which can be either a container in a distribution system, an automated guided vessel in a transport network leopard drum throne or a vessel in a maritime environment with obstacles.It can be applied to several kinds of prob

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Erect panicle super rice varieties enhance yield by harvest index advantages in high nitrogen and density conditions

The erect panicle (Ep) type is an important characteristic for japonica super rice in Northeast China and plays a significant role in enhancing yield.The Ep type is considered to hot topic guy funko pop be a genetic ideotype resource to the japonica super rice group by virtue of its agronomic advantages such as grain number per panicle and biomass.

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Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities

Cynara cardunculus (Cc) is a multipurpose species; beyond its use in southwestern European cuisine, it is also used for the production of solid biofuel, seed oil, biodiesel, paper pulp and cheese, as well as animal feed.In addition, Cc has a long tradition of use in folk medicine as a diuretic and liver protector.The value of this species as a sour

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